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Mixed lineage leukemia is characterized by chromosomal translocations of the mixed lineage leukemia (MLL) gene to form fusion proteins with partner proteins. Many of these MLL-fusion …
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At MLL, the data from the sequencing devices is transferred directly to the Amazon Web Services (AWS) cloud in Frankfurt and analyzed in Illumina's BaseSpace Sequence Hub. Data protection requirements are complied with in accordance with the EU General Data Protection Regulation (GDPR) and ensured via ISO 27001 (Cloud Computing). ...
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The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
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The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of acute leukemias.
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The Mixed Lineage Leukemia gene (MLL) is altered in leukemia by chromosomal translocations to produce oncoproteins composed of the MLL N-terminus fused to the C-terminus of a partner …
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The MLL gene is defined as a gene that encodes a large nuclear protein involved in modifying chromatin to mark specific areas of chromosomes for active transcription. It plays a crucial role …
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Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data …
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MLL-fusions can create oncogenic transcription factors that cause aberrant transcriptional regulation of oncogenes or tumor suppressors to initiate oncogenesis. Start with these targets. MLL1. MLL1 is processed into two polypeptides, both which are subunits of the wild-type MLL complex. The amino terminus of MLL1 is what is included in the ...
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MLL Münchner Leukämielabor Max-Lebsche-Platz 31 81377 München. T +49 89 99017-0 F +49 89 99017-111 info@mll. Report request, sample notification, requests for diagnostics T +49 89 99017-0. MLL MVZ T +49 89 99015-560. Follow MLL on: Newsletter Sign up:
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Chromosomal translocations of the gene encoding the mixed lineage leukemia (MLL) protein are recurrent genetic abnormalities found in patients with AML and in patients …
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In acute myeloid leukemia (AML) a partial tandem duplication (PTD) of MLL occurs in about 5%–11% 1 – 4 of patients and has been linked to poor treatment outcome. 1, 5 Although …
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